Draft a detailed analysis of the Simulation Hypothesis as proposed by Nick Bostrom. Break down the trilemma: (1) humanity will go extinct before reaching a post-human stage, (2) post-human civilizations will have no interest in running simulations, or (3) we are almost certainly living in a simulation. Evaluate the counter-arguments regarding the physical constraints of simulating a universe and the problem of infinite regress. Conclude with the implications of this theory on human ethics and epistemology.