Design a comprehensive framework for conducting a systematic literature review in the field of climate adaptation strategies. Include detailed methodologies for: (1) defining research questions and inclusion/exclusion criteria, (2) developing systematic search strategies across multiple databases, (3) screening and selecting studies, (4) assessing quality and risk of bias, (5) extracting and synthesizing data, (6) identifying research gaps and future directions. Address how to handle heterogeneity in studies, integrate quantitative and qualitative findings, and ensure reproducibility of the review process.