Evaluate the Simulation Hypothesis as proposed by Nick Bostrom. Break down the trilemma into its three components: 1. Humanity will go extinct before reaching a post-human stage. 2. Post-human civilizations will have no interest in simulating their ancestors. 3. We are almost certainly living in a simulation. Discuss the computational and theoretical constraints required to simulate a universe indistinguishable from reality, including concepts like substrate independence and observer effects.