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KI-Glossar

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Leaky Integrate-and-Fire (LIF)

Simplified neuronal model that integrates input currents with a leak representing membrane charge loss, generating a spike when the potential reaches a predefined threshold before resetting.

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Hodgkin-Huxley

Mathematical model describing action potential dynamics through coupled differential equations representing time-varying ionic conductances.

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Izhikevich

Hybrid neuronal model combining the dynamic richness of Hodgkin-Huxley with the computational efficiency of LIF, capable of reproducing multiple neuronal firing regimes.

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Action potential

Transient and brief electrical signal generated by neurons when they exceed their excitation threshold, propagating along the axon to transmit information.

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Firing threshold

Critical value of membrane potential beyond which a neuron generates an action potential, determining neuronal sensitivity to incoming stimuli.

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Refractory period

Time interval following a spike during which the neuron is temporarily unable to generate a new action potential, divided into absolute and relative phases.

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Synaptic current

Flow of electrical charges across synapses in response to neurotransmitters, modifying the postsynaptic membrane potential according to their excitatory or inhibitory nature.

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Membrane conductance

Measure of neuronal membrane permeability to ions, varying dynamically according to the opening and closing of voltage-dependent ion channels.

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Membrane time constant

Parameter characterizing the speed of membrane potential change in response to stimuli, determined by membrane resistance and capacitance.

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Stochastic differential equation

Mathematical formulation incorporating random terms to model neuronal noise and intrinsic variability of neuronal responses to stimuli.

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FitzHugh-Nagumo model

Two-dimensional simplification of the Hodgkin-Huxley model capturing the essence of neuronal excitability with a recovery variable and a fast activation variable.

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Spike-timing-dependent plasticity (STDP)

Learning mechanism where synaptic modification depends on the relative timing of pre- and postsynaptic spikes, strengthening or weakening connections according to their temporal correlation.

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Temporal encoder

Mechanism for converting analog information into temporal spike trains, where information is encoded in the precise timing of action potential firing.

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Adaptive exponential integrate-and-fire neuron (AdEx)

Neuronal model extending LIF with exponential adaptation dynamics to reproduce regular, bursting, and adaptive firing regimes observed in vivo.

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Morris-Lecar model

Two-variable model describing neuronal excitability with calcium and potassium dynamics, particularly suited for studying oscillations and bifurcations.

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Excitatory postsynaptic potential (EPSP)

Gradual depolarization of the postsynaptic membrane potential increasing the probability of spike generation, resulting from the activation of excitatory synapses.

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Potentiel postsynaptique inhibiteur (IPSP)

Hyperpolarisation ou shunt inhibiteur du potentiel membranaire postsynaptique réduisant la probabilité de décharge neuronale, médié par les neurotransmetteurs inhibiteurs comme GABA.

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Dynamique temporelle

Évolution des variables neuronales dans le temps, incluant les changements de potentiels membranaires, les états de canaux ioniques et les patterns de spikes.

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Variable de récupération

État interne du neurone modélisant les processus d'inactivation lente et d'adaptation, contrôlant la période réfractaire et la régulation de la fréquence de décharge.

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Conductances ioniques

Paramètres décrivant la perméabilité sélective de la membrane aux différents ions (Na+, K+, Ca2+ Cl-), régulés par des canaux voltage-dépendants ou chimiquement contrôlés.

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