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Multi-Sequence Alignment Algorithm Design

#bioinformatics #algorithms #optimization

Optimize an algorithm for aligning protein sequences with high computational efficiency.

Propose an algorithm for Multiple Sequence Alignment (MSA) of protein sequences that improves upon the progressive alignment method (like ClustalW) by incorporating consistency-based scoring. Discuss the computational complexity of your approach and how it handles gaps and mutations in conserved regions differently from standard dynamic programming approaches.