Provide a comprehensive theoretical analysis of Nick Bostrom's Simulation Argument. Break down the trilemma it presents: 1) The fraction of human-level civilizations that reach a post-human stage is close to zero, 2) The fraction of post-human civilizations interested in running ancestor-simulations is close to zero, or 3) The fraction of all observers with human-type experiences that live in a simulation is close to one. Discuss the mathematical probability of each disjunct and the implications for our understanding of reality, consciousness, and the limits of empirical science in detecting a simulated environment.